Precision Prediction & Precision Medicine
Assessing skin advanced end products (sAGEs) by skin autofluorescence (SAF) has been proposed as a potential surrogate marker for the risk of developing complications of T1D. The aim of this study was to investigate if SAF reflects glycemic control expressed by HbA1c in a homogeneous population of children and adolescents with T1D.
The researchers performed a cross-sectional analysis in 77 patients with T1D and 118 healthy controls (age range 11-19 years). The impact of current and past HbA1c values, and other factors, was investigated in a retrospective follow-up cohort study.
The researchers noted that, consistent with previous studies, patients with T1D showed significantly higher SAF than controls, even in the youngest age category. They suggested that for the majority of patients SAF “does not seem to provide information additional to HbA1c”.
However, the presumed correlation of high HbA1c with high SAF, and vice versa, did not exist in all patients, in whom “use of this non-invasive measure may provide a surrogate marker for diabetic complications, additional to HbA1c”.