Improvement of Care & Outcome


Mul D, Aanstoot HJ, Simm D, Veeze HJ.

Initial insulin dosage in new onset pediatric diabetes: how to start? Presented at: 8th International Conference on Advanced Technologies and Treatments for Diabetes, 18-21 February 2015, Paris. Abstract: #286.

This Diabeter study was an evaluation of the dosing calculator in our disease management system VCare, when used in children and adolescents newly diagnosed with T1DM. The calculator uses published and collected data on factors influencing the required insulin dose, to produce dosage advice tailored to individual patients, for use at home. Patients receive dosing advice for regular insulin at breakfast and lunch, rapid-acting insulin at dinner, and long-acting insulin as basal insulin.


For this evaluation, the researchers analyzed data on 82 patients (age at diagnosis 2.5-17.8 years) during their first 10 days of insulin treatment.


Key findings:

  • Mean glucose levels fell from 18.1 mmol/L on day 1, to 11.8 mmol/L on day 5, to 8.6 mmol/L on day 10.
  • Of a total of 3,070 glucose measurements, 3 were < 2.7 mmol/L, 67 were < 3.9 mmol/L, and 3 were > 33.3 mmol/L.
  • By day 5, 50% of patients had glucose measurements <12 mmol/L. By day 8, 50% of patients had measurements < 10 mmol/L.
  • No cases of night-time hypoglycemia were reported.


The researchers concluded that the VCare dosing advice “is feasible and safe for home dosing of insulin” and that providing patients with pre-scheduled doses of insulin resulted in “normalization of glucose values within 10 days”. They added: “The safety of the dosage advice allows the family to adapt to the new situation with diabetes without fear for hypoglycemia”.


For abstract click here (page A-126)
For poster click here

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