Improvement of Care & Outcome


Mul D, Aanstoot HJ, Simm D, Veeze HJ.

Initial insulin dosage in new onset pediatric diabetes: how to start? Presented at: 8th International Conference on Advanced Technologies and Treatments for Diabetes, 18-21 February 2015, Paris. Abstract: #286.

This Diabeter study was an evaluation of the dosing calculator in our disease management system VCare, when used in children and adolescents newly diagnosed with type 1 diabetes. The calculator uses published and collected data on factors influencing the required insulin dose, to produce dosage advice tailored to individual people with type 1 dabetes, for use at home. People with type 1 diabetes receive dosing advice for regular insulin at breakfast and lunch, rapid-acting insulin at dinner, and long-acting insulin as basal insulin.


For this evaluation, the researchers analyzed data on 82 people with type 1 diabetes (age at diagnosis 2.5-17.8 years) during their first 10 days of insulin treatment.


Key findings:

  • Mean glucose levels fell from 18.1 mmol/L on day 1, to 11.8 mmol/L on day 5, to 8.6 mmol/L on day 10.
  • Of a total of 3,070 glucose measurements, 3 were < 2.7 mmol/L, 67 were < 3.9 mmol/L, and 3 were > 33.3 mmol/L.
  • By day 5, 50% of people with type 1 diabetes had glucose measurements <12 mmol/L. By day 8, 50% had measurements < 10 mmol/L.
  • No cases of night-time hypoglycemia were reported.


The researchers concluded that the VCare dosing advice…

" feasible and safe for home dosing of insulin” and that providing patients with pre-scheduled doses of insulin resulted in “normalization of glucose values within 10 days”. They added: “The safety of the dosage advice allows the family to adapt to the new situation with diabetes without fear for hypoglycemia" -

For abstract click here (page A-126)
For poster click here

< Back

© 2024 Diabeter | Terms of Use | Privacy Statement