Precision Prediction & Precision Medicine

Glycemic variability and pregnancy

The influence of glycaemic variability in the preconception period in women with type 1 Diabetes on the occurrence of pregnancy- and perinatal complications (GLYVAP4)

In November 2019-2020 Riëlle Hogchem did her 24-week internship at Diabeter, working on the GLYVAP4 study as part of her graduation project. She is a medical student from the Vrije Universiteit Amsterdam, interested in Obstetrics, specifically in high-risk pregnancies. 

"I want to contribute to a safe pregnancy in mothers with Type 1 Diabetes!" -

Pregnancy in women with type 1 diabetes is associated with higher complication risks, which can be reduced by optimal glycaemic control before and during pregnancy. It is known that pre-conceptional HbA1c levels <6,5% are associated with lower risk of congenital anomalies. However, it has also been shown that perinatal and neonatal complications remain high despite adequate glycaemic control in women with type 1 diabetes. It is not yet known if and to what extent pre-conceptional glycaemic variability is associated with pregnancy- and perinatal complications.


The GLYVAP4 study (influence of GLYcaemic VAriability in the Preconception Period in women with diabetes mellitus type 1 on the occurrence of Pregnancy- and Perinatal complications) is a retrospective study which will assess if there is an association between pre-conception glucose variability and pregnancy/perinatal maternal and neonatal complications. If so, glycaemic variability could facilitate identification of high-risk pregnancies in women with type 1 Diabetes.


The results of the study have been submitted and will be shared here once they have been published.

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