Carotid intima-media thickness (cIMT) – a surrogate marker of subclinical atherosclerosis – is significantly higher in people with T1D, even in children and adolescents, compared with controls, according to the results of this study.
The cIMT was measured in a total of 178 patients with T1D, aged 9-22 years, and 208 controls. Classical cardiovascular and diabetes-related risk factors were also assessed. The patients were divided into two groups (younger than, and older than, 15.3 years), to investigate any effect of age.
- Median cIMT was significantly higher in patients aged <15.3 years and in patients aged >15.3 years, compared with controls (0.423 mm, 0.413 mm, and 0.390 mm, respectively).
- Multiple regression analyses showed that only a few independent risk factors contributed significantly to cIMT: T1D duration, current LDL level, current body mass index, and past HbA1c.
- The researchers concluded that cIMT was “significantly and equally increased” in both patient groups (< and > 15.3 years), and that this increase was largely independent of classical and diabetes-related risk factors.
- They added that contributing factors “are likely related to innate immunity and inflammation, autoimmunity and epigenetic changes”.
For Pubmed abstract click here.